Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia

  • I Mweene-Ndumba
  • S Siziya
  • M Monze
  • ML Mazaba
  • F Masaninga
  • P Songolo
  • P Mwaba
  • OA Babaniyi
Keywords: Seroprevalence, West Wile Virus, Western province, North-Western province, Zambia

Abstract

Background: West Nile Virus (WNV) infection has been reported worldwide, including in Africa but its existence in Zambia is unknown. Symptoms for the virus include headache, myalgia, arthralgia and rash.
Objectives: This study aimed to determine the seroprevalence of WNV and its correlates.
Methods: A cross sectional study was conducted in North-Western and Western provinces of Zambia. Samples were subjected to IgG and IgM antibodies testing against WNV. Logistic regression analyses were conducted to determine magnitudes of association.
Results: A total of 3,625 of persons participated in the survey out of which 10.3% had WNV infection. Farmers were 20% (AOR=0.80; 95% CI [0.64, 0.99]) less likely to have infection compared to students. Meanwhile participants who lived in grass roofed houses were 2.97 (AOR=2.97; 95% CI [1.81, 4.88]) times more likely to be infected than those who lived in asbestos roofed houses. IRS was associated with reduced risk of infection (AOR=0.81; 95% CI [0.69, 0.94]). Travelling to Angola was associated with the infection [AOR=1.40; 95% CI [1.09, 1.81].
Conclusion: Spraying houses with insecticide residual spray would minimize mosquito-man contact. Furthermore, surveillance at the border with Angola should be enhanced in order to reduce importation of the virus into the country.


Keywords: Seroprevalence, West Wile Virus, Western province, North-Western province, Zambia

Published
2015-09-09
Section
Articles

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eISSN: 1680-6905