Main Article Content

Ultrasonographic and biochemical assessments as early prediction of polycystic ovarian syndrome in obese women


Alaa A Ahmed
Said S Moselhy
Taha A Kumosani
Etimad A Huwait
Maryam A AL-Ghamdi
Khalid A AL-Madani
Majdi H AlToukhi
Afnan T Kumosani

Abstract

Backgroud: Polycystic ovary syndrome (PCOS) is considered as a common cause of hormonal disturbance and obesity. The diagnosis of PCOS was done by different methods including clinical signs as anovulation, hyperandrogenism, biochem- ical markers and ultrasounographic investigation. This study investigated comparative outcomes of ultrasonographic and biochemical markers for early prediction of PCOS in obese women.


Subjects and methods: Seventy-five patients were clinically diagnosed with obese, PCOS and obese with PCOS and twen- ty-five normal age matched subjects were enrolled as control. Abdominal and transvaginal ultrasonographic for assessment of ovarian properties. In addition, BMI, serum free testosterone, dehydroepiandrosterone (DHEA), insulin, glycosylated hemoglobin (HbA1c) and LDL-c levels were evaluated.


Results: In obese patients with PCOs (20%) ovaries revealed normal appearance in morphology while the rest (80%) showed PCOs in the form of cysts of 2–8 mm in diameter peripherally arranged around stroma. A significant elevation of free testosterone, DHEA and insulin in obese with or without PCOS compared with obese group (p<0.001). A positive correlation with hormonal abnormalities of increased HA1c, LDL-c, free testosterone, DHEA and insulin compared with obese only.


Conclusion: According to our study findings, ovarian morphology combined with biochemical markers is more reliable for early prediction and diagnosis of PCOS for interpretation and management.


Keywords: PCOS; ultrasound; diagnosis; hormones.

     View our Diamond Open Access Survey (closes on February 29, 2024)


Journal Identifiers


eISSN: 1729-0503
print ISSN: 1680-6905