Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus

  • Oloruntoba A Ekun
  • Oloruntoba F Fagbemi
  • Esther N Adejumo
  • Oyeronke O Ekun
  • Kehinde S Wojuade
  • Folu M Oshundun
  • Florence O Adefolaju
  • Sade R Oyegbami
Keywords: Type 2 diabetes mellitus; renal disease; glycated haemoglobin; high sensitivity C-reactive protein.

Abstract

Background: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications.

Objective: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM).

Methods: 160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines.

Result: The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications.

Conclusion: Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population.

Keywords: Type 2 diabetes mellitus; renal disease; glycated haemoglobin; high sensitivity C-reactive protein.

Published
2022-10-28
Section
Articles

Journal Identifiers


eISSN: 1729-0503
print ISSN: 1680-6905