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Published:
Jul 13, 2023DOI:
10.4314/ahs.v23i2.6Keywords:
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Main Article Content
Interferon in the treatment of ill adults with Covid-19 in the Republic of Guinea
Abstract
Background: Effective and safe antiviral treatments are required to refrain the COVID-19.
Objectives: Investigate the efficacy and safety of interferon in the treatment of COVID-19.
Methods: The inclusion criteria were patients who gave their signed consent, with detection confirmed by RT-PCR of SARSCoV- 2, 18 years and older. Patients received therapy as per the Guinea COVID-19 protocol in the group B; the group A received the same treatment including administration of interferon. The outcome measures the time to negative conversion of SARSCoV- 2, mortality, patients transferred to ICU and safety, according to the reports of adverse events.
Results: 345 patients were included, 171 in the group A and 174 in the group B. After the treatments, the RT-PCR negative results were attained in the patients in the group A in 9.15±4.79 days and in those in the group B in 14.83±6.67 days. No patient in the group A had to be transferred to ICU, and they all survived; in the group B, 26 patients were transferred to ICU and six of them died. There were eight adverse events with causality relation with interferon administration.
Conclusions: The interferon resulted effective and safe in contributing to the viral replication conversion to negative results in shorter time and to survival.
Keywords: SARS-Cov-2; COVID 19; zoonosis; human recombinant interferon.
