Ferulic acid ester from the stem bark of Acacia ataxacantha

  • A.A. Ahmadu
  • A. Agunu
  • B.A. Lawal
Keywords: Acacia ataxacantha, tetradecanyl ferrulate, protein kinase

Abstract

From the chloroform extract of the stem bark of Acacia ataxacantha, a ferrulic acid derivative identified as n-tetradecanyl-3-methoxy-4-hydroxy –trans-cinnamate (tetradecanyl ferulate) compound 2 was isolated for the first time from this plant alongside the triterpene lupenol. The structure of compound 2 was confirmed using NMR and MS and is reported here for the first time. Primary activity of the isolated compound against a panel of disease related protein kinases reveal the compound to be in-active.

Keywords: Acacia ataxacantha, tetradecanyl ferrulate, protein kinase

Afr. J. Biomed. Res. Vol. 22 (May, 2019); 214- 217

Author Biographies

A.A. Ahmadu
Department of Pharmaceutical and Med. Chemistry, Kaduna State University, Kaduna-Nigeria
A. Agunu
Department of Pharmacognosy and Drug Development, University of Ilorin-Nigeria
B.A. Lawal
Department of Pharmacognosy and Drug Development, University of Ilorin-Nigeria
Published
2019-10-27
Section
Articles

Journal Identifiers


eISSN: 1119-5096