African Journal of Biomedical Research

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Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

NM Abdel-Hamid


To assess the protective effect of diphenyl dimethyl bicarboxylate (DDB)
in carbon tetrachloride (CCl4) – induced fatty liver in male rats .Fatty
liver was induced by single intraperitoneal ( IP ) CCl4 dose of 0.2mL /kg ,
treated group was given the same CCl4 dose , then given oral daily doses
of DDB as 300 mg /kg body weight for 4 weeks . A control group , given
saline orally was run against the other two groups . Each group consisted
of 10 male Wistar albino rats. Liver weight ( in g ) , liver tissue contents of
total protein ( TP) , total lipids (TL) , phospholipids (PL) , total cholesterol
(TC) and triglycerides (TG) as mg / g wet tissue were investigated. CCl4
treatment significantly increased liver tissue weight , TL ,TC , TG , but
decreased both TP and PL . DDB treatment after CCl4 intoxication ,
recovered these variables near normalcy. The study substantiates the
protective action of DDB against CCl4 – induced fatty liver , through
assessment of most tissue parameters known to be disrupted in fatty liver.
The drug significantly decreased both liver weight ,TL ,TC ,TG and
increased both PL and TP , so improved fat mobilization from chemicalinduced
fatty liver (Afr. J. Biomed. Res. 9:77 – 81, May 2006)

Keywords: Fatty liver , rats , carbon tetrachloride , DDB , total protein , total lipids ,total cholesterol , phospholipids , triglycerides
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