African Journal of Biomedical Research

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Antimicrobial Potency of Pentaclethra Macrophylla Seed Extract on Seven Selected Pathogens

JO Olaitan, SO Kareem, SO Dada


The antimicrobial efficacy of extracts of Pentaclethra macrophylla in ethanol, methanol and water was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella species, Salmonella typhi, Aspergills niger and Candida albican using paper disc and hole diffusion methods. The results revealed that the growths of test organisms were inhibited by extracts used. The least inhibitory zone (25.0mm) was best recorded in ethanol extract against A. niger and C. albicans. The minimum inhibitory concentration of the extracts ranges between 62.5-250mg/ml on the test isolates. However, the antimicrobial potency of Pentaclethra macrophylla was more prominent against bacterial isolates than fungal isolates. These findings lend more weight to the use of Pentaclethra macrophylla seed for therapeutic purposes.

Keywords: Pentaclethra macrophylla, antibacterial, microorganism

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