Results of prostatic biopsies in Algerian patients with an elevated PSA and/or suspicious digital rectal examination
Keywords: Prostate cancer, Digital Rectal Examination, PSA, Biopsy
AbstractObjective: to report on prostatic biopsy results in Algerian patients presenting with a suspicious Digital Rectal Examination (DRE) and\or an elevated total PSA.
Methods: data collected on prepared index cards were age, result of DRE, rate of PSA and number of cores, as well as the histological result. The biopsies were performed by two urologist surgeons from Oran city, Algeria.
Results: 331 patients had prostatic transrectal ultrasound-guided biopsies, the average (SD) age was 70.4 (8.7) years with a range 33 - 94 years. The most important age bracket was the one with subjects over 60 years. The DRE was suspicious in 41.69% of patients (138 of 331), and 44.20% of the suspect prostates on DRE were malignant. The average PSA was 42.2 ng/ml the rate of PSA >10 ng/ml constituted 72.57%. The number of biopsy cores was 12 for 129 biopsies, 49.2% of the biopsies revealed prostatic adenocarcinoma. The percentage of positive biopsies was 41.66% (21/48) when the PSA was between 4 and 10 ng/ml, and 33.33% (45/135) when the PSA exceeded 10 ng/ml. Among 47 scores of Gleason 59.7% patients had a score 7, 8.6% had a score < 7, and 31.8% had scores >7.
Conclusion: 49.2% of 331 biopsies were positive for prostatic adenocarcinoma. Significant associations were found between age and cancer, between digital rectal examination and prostate biopsy results, and between PSA and number of positive cores.
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