Histomorphological alteration of lung and GIT function and possible alleviative role of herbal medicine (<i>Zingiber officinale, Curcuma longa, Garcinia kola</i>) on wistar rats

Abstract

Background: Herbal medicine is widely used globally for different purposes. It is used as a curative medicine, preventive medicine, food supplement and also serve economic purpose here in Nigeria.

Aim: This research item is aimed at evaluating the Histomorphological alteration of lung and GIT function and possible role of herbal medicine (Zingiber officinale, Curcuma longa, Garcinia kola) on wistar rats.

Materials and Methods: A total of 40 rats were used for this research. The research was carried out in two phases. Stage 1, was divided into two groups (1 and 2). Group 1 with 6 rats was used as control while group 2 received 10mg /kg of cyclophosphamide made up of 34 rats. After 5 weeks, the animals were weighed, anaesthetized, 6 of the 34 rats were sacrificed alongside the control and organ of interest harvested and examined histologically. In the stag 2, the remaining 28 rats were further divided into seven groups, group A-G, with four rats in each group, A, B, C, D, E, F and G received water and rat pellet, 600 mg/kg weight of Zingiber officinale, Curcuma longa, Garcinia kola respectively, 600mg / kg, 1200mg / kg and 2400mg / kg per b/w of combine extract respectively. After six weeks period, all animals were weighed, anaesthetized and sacrificed GIT and lungs harvested for histological examination.

Results: Significant weight loss, inflammation of the git and lung tissue in rats treated with cyclophosphamide, amelioration of the aforementioned degeneration was seen in pooled extract treated rats

Conclusion: The result shows that the plant extracts has reparative potential.