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Assessment of bladder tumour antigen in ovarian and cervical cancer patients


O.O. Odewusi
O.E. Ogundiran
E.A. Omon
S.O. Obadire
A.O. Akande,
B.E. Ogunbusuyi

Abstract

Background: Bladder cancer is a relatively rare type of cancer that begins in the cells of the bladder, while cervical and ovarian cancers  are the most common malignancies of the female genital tract specifically the cervix and ovaries. Cervical and ovarian cancer continues  to be a major public health problem affecting middle – aged women, particularly in resource limited countries.


Aim: The research aimed to assess the bladder tumor antigen (BTA) in ovarian and cervical cancer subjects.


Methodology: The BTA was estimated using ELISA method. The results were presented in tables and charts as mean ± SD. Statistical  analysis was done using ANOVA and Student’s t-test using Statistical Package for Social Sciences (SPSS) version 23. A p-value <0.05 was  considered significant.


Results: The result of this study showed that BMI was significantly higher in treated and untreated ovarian and cervical cancer subjects  compared with control (p<0.05). Furthermore, BTA was significant higher in treated and untreated cervical and ovarian cancer subjects  compared with control (p<0.05) and significantly lower in treated ovarian and cervical cancer subjects compared to untreated ovarian and  cervical cancer subjects respectively (p<0.05). In all age groups, BTA was significantly lower in treated ovarian and cervical cancer  subjects compared with untreated ovarian and cervical cancer subjects respectively (p<0.05).


Conclusion: Cervical and ovarian cancers  are risk factors of bladder cancer as BTA level was significant increase in ovarian and cervical subjects compared with healthy control subjects. Due to its high sensitivity and specificity, BTA can be used in the detection of bladder cancer particularly in women with cervical  and ovarian cancer.