Borno Medical Journal July-December 2019 Vol. 16 Issue 2 Page 1 This work is licensed under a Creative Commons Attribution 4.0 International License Changes in Corneal Endothelial Cells Following MSICS VERSUS Conventional ECCE in a Tertiary Eye Hospital i

Abstract

Background: This study was undertaken to compare the effect of two surgical techniques of cataract extraction on corneal endothelial  cell density in eyes of Nigerian adults with uncomplicated age-related cataract with the view to improving surgical visual function and quality of life.

Materials and Methods: It was a prospective randomized non blinded hospital based interventional study. Two hundred  and seventy-seven (277) eyes of 269 eligible patients with cataract were randomized to either manual small incision cataract surgery (MSICS) or conventional extracapsular cataract extraction (ECCE). The endothelial cell density (ECD), Coefficient of variation (CV), and Hexagonality  (%) were measured pre-operatively, at one, four and twelve weeks post-operatively with a non-contact specular microscope (CSO SP 02). Statistical analysis – Data obtained were entered into microsoft Excel and analyzed using SPSS version 16 software.

Result: Of the 277  eyes studied, 263 (94.9%) were analysed. The mean age of patients for MSICS and ECCE was 64.03 (SD + 11.2, range 40 – 95 years) and  62.69 (SD +10.48, range 42 – 94 years) respectively. The Male to female ratio was 1.9:1, in the two study groups. Pre-operatively, corneal  parameters (mean ECD, CV and hexagonal cells) were similar between the two surgery groups. Postoperatively cataract surgery induced  a mean endothelial cell density loss of 5.31% at one week, 7.28% at 4 weeks and 7.06% at 12 weeks in the study population. There was no  statistically significant difference in the mean endothelial cell density loss between MSICS and ECCE groups.

Conclusion: Both MSICS and  ECCE induced fairly equal moderate and reversible degree of endothelial cell density loss in adults with uncomplicated age related  cataract