Preliminary studies on the efficacy of aloe vera (Aloe barbadensis) extracts on experimental Trypanosoma brucei brucei infection of mice
AbstractExtracts of Aloe vera were administered to experimentally infected mice with the Nigeria strain of Trypanosoma brucei brucei. The thirty-two (32) mice involved in the study were split into eight (8) groups of 4 mice each and treated intraperitoneally with the aqueous and ethanolic Aloe vera extracts of 40, 80, 20 mg/Kg body weight of aqueous extracts and 3.5mg/Kg (Berenil®). The untreated with 3.5mg/Kg (standard trypanocidal drug) achieved aparasitaemia of 3 days post treatment. The toxicity of the extract to the parasite was concentration-dependent. 80mg/Kg aqueous extract showed the most significant reduction in parasitaemia and effected the most dramatic post treatment reduction. This was followed by 40mg/Kg aqueous extract treatment regimen. The haematocrit value decreased with increasing concentration of both the aqueous and ethanolic extracts.
Bio-Research Vol. 3(1) 2005: 21-25
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