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Gastric erosions were induced in rats with indomethacin, 5-hydoxytryptamine (5-HT) or reserpine. Three adenine compounds adenosine, adenosine, 5 /-adenosine monophosphate (AMP) and 5 /- adenosine diphosphate (ADP) were found to protect against the erosion formations. Both 5-HT and reserpine caused untimely deaths of some of the control animals. Also the adenine compounds prevented the untimely deaths caused by the two ulcerogenes.
Keywords: Adenosine, AMP, ADP, Anti-ulcer, Antidote, Gastric erosion
Bio-Research Vol. 6 (1) 2008: pp. 346-347