Anti-inflammatory, analgesic and antipyretic activities of the ethanol extract of the seeds of buchholzia coriacea in experimental animals

  • OC Enechi
  • FC Ibeafu
  • K Ledee
  • OFC Nwodo
Keywords: Anti-Inflammatory, Analgesic, Antipyretic, Ethanol extract, Buchholzia coriacea, Rat

Abstract

The effects of the ethanol extract from Buchholzia coriacea seed on inflammatory response using fresh egg albumin- induced paw edema in rats were examined. Antinociceptive activity of the extract using writhing test with acetic acid-induced pain in mice and the antipyretic activity in yeast- induced fever in rats were also examined. Oral administration of the extract (at the dose of 400mg/kg and in a dose dependent manner) significantly (p< 0.05) decreased the paw oedema induced by fresh egg albumin in rats. The extract (at 400mg/kg) also significantly (p< 0.05) inhibited yeast-induced pyrexia in rats when compared to the control. The extract was also found to possess significant (p< 0.05) dose dependent antinociceptive response in mice at 800 mg /kg. The results support the use of Buchholzia extract for the treatment of inflammatory disorders.
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print ISSN: 1596-7409