Ameliorative Potential of <i>Elaeis Guineensis</i> on the Histomorphology and Biochemical Status of Liver and Kidney in Wistar Rats Administered with Selected Narcotics

Abstract

The unguided use of drugs is not new in many Nigerian communities. Oil palm has been in used for eons before now and still being used for vast  purposes. This study aimed to ascertain level of histomorphological and biochemical alteration of narcotics and possible remedies to combat its effects  using Elaeis guineensis Wistar rats. Fifty (50) adult male albino rats were study. They were divided into five (5) equal groups (labeled A to E) of ten (10) rats  in each group. Group A (Control) received only normal feed (growers’ mash) and distilled water, B received 0.2 mg/kg bw of tramadol and 0.2mg/kg  of codeine, feed and distilled water daily, C received 0.2mg/kg of tramadol and 0.2mg/kg of rohypnol, D received 0.2mg/kg of codeine and 0.2 mg/kg bw  of rohypnol, E received 0.2mg/kg of tramadol, 0.2mg/kg of rohypnol and 0.2mg/kg of codeine and Elaeis guineensis extract respectively for 42 days after  which the animals were sacrificed, dissected, blood samples and tissues taken and processed. Significant difference (p< 0.05) observed in creatinine,  alkaline phosphatase value in group C and E, also urea in group B and E, conjugated bilirubin also in group C. Deleterious effect was observed in the liver  and kidney tissue in group B, C and D. Amelioration was observed in group E. E. guinensis had ameliorative potential in the effect of the tested narcotics  out did not have reversal effect on the tissue architectures prior to the usage of the drugs