The study examined the influence of gender, educational level, perceived self-efficacy and achievement striving behaviour on prone-ness of athletes in Ogun State to abuse drugs. Descriptive survey design was adopted. A simple random sampling technique was used to select 304 participants. The age range of participants is between 13 and 35, with 138 male and 166 female. Three instruments were used to collect data; and t-test statistical procedure was utilized to analyze data. Results indicated that there is no significant gender, educational level and achievement striving differentials in the prone-ness of athletes to abuse drug, but there is significant difference in the prone-ness to abuse drugs between athletes with high and low self-efficacy. Consequently, it was suggested that measures should be taken to enhance the self-efficacy skills of athletes for better results in the battle against drug abuse among sports men and women.