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International Journal of Biological and Chemical Sciences

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Synthesis of symetrical near-infrared dyes containing benzo[c,d]indole system

Venance Martial Say, Timothée Aboua Okpekon, Sagne Jacques Akpa, Ané Adjou

Abstract


Five symmetrical near infrared dyes having different linker between the two heterocycles were synthesized by condensation of N-alkylbenzo[c,d]indolium salts with either squaric acid or imine. All synthesized dyes showed strong absorbance in the near-infrared region of 850-1015 nm and can be used as nucleic acid detection or fluorescent labeling agents for proteins. Three of the dyes 21, 22 and 25 containing functionalized N-substituents (ester group) can be further modified or covalently attached to target. The structures of these cyanine dyes where characterized by virtue of NMR, UV, MALDI and Elemental analysis.

Keywords: Synthesis, cyanine, Polymethine dyes, Near-IR dyes, Absorption, Chromophore.




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