Article Sidebar
Article Details
Issue
Section
Articles
Submission of a paper for publication implies the transfer of the copyright from the author(s) to the publisher upon acceptance. International Formulae Group is therefore the copyright holder after publication of an article in International Journal of Biological and Chemical Sciences, and published articles should not be used for commercial purpose without the written consent of the Editor-in-Chief. They are licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License.
Main Article Content
Effect of artemisinin alone and artemisinin with folic acid on the lipid profile of rat
Abstract
Studies were carried out on the effect of artemisinin alone and with folic acid on total cholesterol, triacylglycerol and lipoprotein fractions in the serum of male Wistar rats. Different groups of rats (n=8) were orally given 0.75, 1.50, 3.00 and 6.00 mg/kg body weight of artemisinin, respectively. Each of these groups also was orally administered 1.50 mg/kg of folic acid concurrently. Analyses of results showed a significant (P<0.05) increase in the level of total cholesterol in the serum from 2.479 ± 0.25 to 3.964 ± 0.21 mmole/L. In
contrast, triacylglycerol level decreased simultaneously from 0.75 ± 0.11 to 0.414 ± 0.04 mmole/L. The ratio of the Low Density Lipoprotein to High Density Lipoprotein reversed from 1:2 to 2:1. These results suggest that
folic acid offers complete relief to lipid disorders associated with low doses of artemisinin but partial relief to the same disorder caused by high doses of the drug.
contrast, triacylglycerol level decreased simultaneously from 0.75 ± 0.11 to 0.414 ± 0.04 mmole/L. The ratio of the Low Density Lipoprotein to High Density Lipoprotein reversed from 1:2 to 2:1. These results suggest that
folic acid offers complete relief to lipid disorders associated with low doses of artemisinin but partial relief to the same disorder caused by high doses of the drug.
