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Journal of Pharmaceutical and Allied Sciences

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Comparative evaluation of antidiabetic activities of Flavonoids extract and crude methanol extract of loranthus Micranthus parasitic on

IC Uzochukwu, PO Osadebe

Abstract


The antidiabetic activities of flavonoids extract (FE) and crude  methanol extract (CME) of Loranthus micranthus parasitic on Kola acuminata were studied in alloxan-induced diabetic rats. Four groups of rats (n=4) were given 100 and 200 mg/kg of FE and CME respectively by the intraperitoneal route. Glibenclamide (10 mg/kg) and tween 80 (2 ml/kg) were also administered intraperitoneally as positive and negative
control respectively. While the FE (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within one hour of administration in the treated rats, the CME (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within three hour of administration in the treated rats. The result shows that the antidiabetic activities of L. micranthus parasitic on K. acuminata may be attributable to the flavonoids contents of the leaves.



http://dx.doi.org/10.4314/jophas.v4i1.48448
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