Fasting blood glucose and glycosylated haemoglobin levels in randomly selected ghanaian diabetic patients – the clinical implications

  • FKN Arthur Department of Biochemistry, Kwame Nkrumah University of Science and Technology, Ghana
  • FA Yeboah Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Ghana
  • K Nsiah Department of Biochemistry, Kwame Nkrumah University of Science and Technology, Ghana
  • PKN Nkrumah Department of Biochemistry, Kwame Nkrumah University of Science and Technology, Ghana
  • KA Afreh Department of Biochemistry, Kwame Nkrumah University of Science and Technology, Ghana
  • K Agyenim-Boateng Department of Medicine, Komfo Anokye Teaching Hospital

Abstract

This work involved the measurement of fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c) levels of diabetes mellitus patients as an index of glycaemic control. It was a prospective case-finding study using laboratory and general practice records. The subjects were confirmed diabetic patients, attending a Diabetic Clinic at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. The fasting blood glucose levels were measured in millimolar concentration and corrected glycosylated haemoglobin (HbA1c) levels expressed as percentages. The mean level of fasting blood glucose (± standard deviation) for the non-diabetics was 4.91 ± 1.08 mmol/L and the corresponding mean value for the HbA1c was 5.40 ± 0.84%. There was a linear correlation between the fasting blood glucose and HbA1c. Out of the 99 diabetics, 9 of them had near-normal levels of HbA1c while 64 had mean values between 12 and 16%. There was generally high levels of glycosylated haemoglobin in the majority of patients studied, reflecting their poor glycaemic control. This suggests a relatively large proportion of the diabetics could be predisposed to microvascular complications, while a small group with near-normal HbA1c levels could be prone to hypoglycaemic complications.

Journal of Science and Technology Vol. 25(2) 2005: 13-17
Published
2006-05-17
Section
Articles

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eISSN: 0855-0395