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The research examines the proﬁt efﬁciency of sorghum production among smallholder farmers in the Southern Agricultural Zone of Nasarawa State, Nigeria. Utilizing a multi-stage sampling method, 200 sorghum growers were selected as sample size for the study. Data were analyzed using Descriptive Statistics, Gross Margin and Stochastic Proﬁt Frontier Function. Results show average sorghum farmers in the research area had 1.0 ha of farmland under cultivation; production of sorghum was proﬁtable at ₦85,006.63/ha/annum; the return on investment for sorghum production was ₦1.54k; the average Proﬁt efﬁciency was 0.55; while potential proﬁt in the study area was ₦123,259.24/ha/annum. The ﬁndings reveal that the proﬁt lost due to inefﬁciency was statistically signiﬁcant at ₦38,252.87/ha/annum the coefﬁcients of seed price, 0.329(P<0.05) and farm size, 0.807(P<0.05) were major factors inﬂuencing the quantum of proﬁt efﬁciency, while the determinants of proﬁt inefﬁciency were household size (with coefﬁcient 1.040, P<0.05) and access to credit (with coefﬁcient -1.428 P<0.05). Constraints to sorghum production were inadequate credit facility, insecurity, insufﬁcient improved seed, and inadequate extension visits. Therefore, for greater proﬁt margins and improved production efﬁciency, sorghum growers should endeavour to adopt improved seeds and have easy access to credit facilities. Farmers' extension contact should be increased and extension services should be packaged to include training on optimal utilization of production inputs and prices. The security architecture in the area should be enhanced to guarantee unhindered and safe access to farmlands.