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The effects of methanol extract of Sesamum indicum seeds (obtained from Kogi state) on male hormonal proﬁle and sperm quality in adult male albino rats was evaluated. Thirty six adult male rats (170 – 200 grams) were randomly divided into four groups replicated thrice with each replicate having three rats. Group A (normal control) and groups B, C and D (test groups) were administered 0, 125, 250 and 500 mg/kg of the extract respectively. Sperm parameters, male hormonal proﬁle and histology of the organs evaluated after 28 days showed that a signiﬁcant (p<0.05) increase in the concentrations of sperm motility, viability and count across all groups treated with methanol(MEOH) extract of Sesamum indicum seeds(SIS) when compared with control group. The percentage normal sperm concentration in the MEOH SIS treated groups decreased signiﬁcantly (p<0.05) while total sperm abnormality concentrations increased signiﬁcantly across all groups when compared with the control group. The percentage of detached head increased signiﬁcantly (p<0.05) across all groups treated with MEOH extract while percentage of bent-mid piece and twisted tail only increased signiﬁcantly (p<0.05) only in the group treated with the 500mg/kg of the extracts when compared with control group. Serum concentration of follicle stimulating hormone (FSH), Leutenizing hormone (LH) and testosterone signiﬁcantly (p<0.05) increased in group treated with 250mg/kg of MEOH SIS extract also, a signiﬁcant (p<0.05) increased was also observed in the concentrations of LH administered 125 mg/kg of the extract when compared with the control group. The histology of the testes of all groups showed intact seminiferous tubules and interstitium with orderly germ cell maturation variable around the tubule. The ﬁndings of this study suggest that methanol extract of Sesamum indicum seeds may possess fertility potentials since it stimulate and improve male hormonal concentration, sperm quality and maintain the architecture of the testes of the adult male albino rats. However, the high dose of 500mg/kg of the extract may be toxic at the administered duration.