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Effects of some synthetic antibiotics on Streptococcus pnemoniae and Proteus mirabilis isolated from cultured Clarias gariepinus, an important food fish raised in a concrete tank was carried out to ascertain their remedies on mortalities of the Clarias gariepinus adult fish. Streptococcus pnemoniae and Proteus mirabilis were isolated from the gill and skin of diseased fish and water samples and identified by standard microbiological methods.The bacteria isolates were tested for sensitivity on ten (10) antibiotics namely Amoxycillin, Gentamicin, Nitrofurantoin, Erythromycine, Augmentin, Tetracycline, Naladoxic aci d, Cotrimoxazole, Cloxacillin and Ofloxacin. These organisms reacted differently to the different antibiotics that were used - Ofloxacine, Gentamycin and Erythromycine had highest zones of inhibition of 26mm and 26mm, 24mm and 19mm, 16mm and 17mm respectively around Streptococcus pnemoniae and Proteus mirabilis, but Naladoxic acid, Augmentin, Cloxacillin and Amoxycillin had no inhibition zones around both organisms. It is therefore recommended that Ofloxacine, Gentamycin and Erythromycine can be used to combat S. pnemoniae and P. mirabilis diseases in fish farms because of their high antibacterial potentials against the test organisms.
Keywords: Streptococcus pnemoniae, Proteus mirabilis, Clarias gariepinus, Synthetic