Synthesis of Imidazol[1,5-a]indole-1,3-diones from Imidazolidene-2,4-diones

  • TO Akeng’a
  • RW Read
Keywords: Indoles, imidazolidine-2, 4-diones, arylaldehyhydes, copper bronze, tributyl tin hydride.

Abstract

Copper and tributyltin hydride catalysed cyclization, through the N-aryl bond formation, of imidazolidine-2,4-diones (11–16,18) yielded imidazo[1,5-a]indole-1,3-diones (5–10) in high yields (72–100%). The ease of cyclization was found to be consistent with the normal halogen reactivity and the type of substituents. The highly substituted imidazole-2,4-dione 15 gave brominated 19 and tin incorporated heterocycles 20 when treated with copper bromide and tributyltin hydride, respectively.


KEYWORDS: Indoles, imidazolidine-2,4-diones, arylaldehyhydes, copper bronze, tributyl tin hydride.

Published
2015-10-06
Section
Articles

Journal Identifiers


eISSN: 0379-4350