Synthesis and Antimicrobial Activity of Some New α-Aminophosphonates

  • K Srinivasulu
  • CN Raju
  • YH Babu
  • ALK Reddy
Keywords: -Aminophosphonates, alkyl/aryl phosphites, aldehydes, amines, antimicrobial activity.

Abstract

Syntheses of new α-aminophosphonates 4a–l were achieved through a one-pot, three-component reaction process (the Kabachnik-Fields reaction). It involves the reaction with substituted salicylaldehydes, amines and dialkyl/diaryl phosphites in dry toluene at reflux temperature. The structures of the novel products were established by elemental analyses, IR, 1H, 13C and 31P NMR and mass spectroscopy. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antimicrobial activity.

KEYWORDS: α-Aminophosphonates, alkyl/aryl phosphites, aldehydes, amines, antimicrobial activity.

Published
2015-10-06
Section
Articles

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eISSN: 0379-4350