Solubility of Crystalline Nonelectrolyte Solutes in Organic Solvents: Mathematical Correlation of 3-Chlorobenzoic Acid Solubilities with the Abraham Solvation Parameter Model
AbstractThe Abraham solvation parameter model is used to calculate the numerical values of the solute descriptors for 3-chlorobenzoic acid from experimental solubilities in organic solvents. The mathematical correlations take the form of
log (CS/CW) = c + e·E + s·S + a·A + b·B + v·V
log (CS/CG) = c + e·E + s·S + a·A + b·B + l·L
where CS and CW refer to the solute solubility in the organic solvent and water, respectively, CG is a gas phase concentration, E is the solute excess molar refraction, V is the McGowan volume of the solute, A and B are measures of the solute hydrogen-bond acidity and hydrogen-bond basicity, S denotes the solute dipolarity/polarizability descriptor, and L is the logarithm of the solute gas phase dimensionless Ostwald partition coefficient into hexadecane at 298 K. The remaining symbols in the above expressions are known solvent coefficients, which have been determined previously for a large number of gas/solvent and water/solvent systems. The Abraham solvation parameter model was found to describe the experimental solubility data and published literature partitioning data of 3-chlorobenzoic acid to within an overall standard deviation of 0.083 log units.
Key Words: 3-Chlorobenzoic acid solubilities, Partition coefficients, Molecular solute descriptors, Solubility prediction
South African Journal of Chemistry Vol.58 2005: 25-29
Copyright for articles published in this journal is retained by the journal.
SAJChem applies the Creative Commons Attribution (CC BY) license to manuscripts we publish. This license was developed to facilitate open access – namely, free immediate access to, and unrestricted reuse of, original works of all types. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute or reuse these articles, as long as the author and original source are properly cited.