Serum levels of antioxidant vitamins in sicklers and non-sicklers in Sokoto Metropolis' children

  • IK Matazu Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M.B.2346 Sokoto, Nigeria.
  • LS Bilbis Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M.B.2346 Sokoto, Nigeria
  • NM Jiya Department of Paediatrics, Usmanu Danfodiyo University Teaching Hospital P.M.B.2370 Sokoto, Nigeria
  • HU Suleiman Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M.B.2346 Sokoto, Nigeria
  • BS Abdulkareem Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M.B.2346 Sokoto, Nigeria
  • UA Abubakar Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M.B.2346 Sokoto, Nigeria

Abstract

The serum concentrations of vitamins A (retinol), C (ascorbic acid) and E (alpha-tocopherol) of paediatric- age group were determined in sicklers and non-sicklers within the Sokoto metropolis. The levels of the antioxidant vitamins were found to be significantly lower (p < 0.001) in the sickler group when compared to that in non-sicklers. In all cases the concentrations of the antioxidant vitamins were significantly depressed in children with sickle-cell anaemia. The depletion in the levels of the three-antioxidant vitamins may probably account for some of the observed clinical manifestations of sickle-cell anaemia. This shall be the subject of our future investigation(s).

Key Words: Sicklers, Non- sicklers, Serum Vitamin A, Serum Vitamin C, Serum Vitamin E.

Sahel Med. J. Vol.6(2) 2003: 53-57
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