Comparative evaluation of lignocaine and lignocainebupivacaine for lumbo-sacral epidural block in diazepam sedated West African dwarf goats
This study compared the onset of neural blockade, onset and duration of analgesia and duration of recumbency produced in five healthy West African Dwarf (WAD) goats by the lumbo-sacral epidural injections of a mixture of 2mg/kg lignocaine 2% solution and 0.95mg/kg bupivacaine 0.5% solution (LBM) and 4mg/kg lignocaine 2% solution. Associated changes in heart rate (HR), respiratory rate (RR) and rectal temperature (RT) were recorded at 10-min intervals in the initial 1 hour. The onset of neural blockade with LBM (9.6±2.7 min) was significantly (p<0.05) longer with LIG (2.8± 0.4 min) the onset (24.8 ± 3.8 min) and duration (113.8± 16.5 min) of analgesia with LBM were significantly (p<0.05) longer than the onset (11.6 ± 2.4min) and duration (68.6 ±14.9min) of analgesia with LIG respectively. The duration of recumbency with LBM (148.0 ± 9.7min) was also significantly (p<0.05) longer with LIG (81.6 ± 6.5). There were no significant differences (p>0.05) in the physiological parameters between the two groups. It was concluded that epidurally administered LBM had a slower onset of neural blockade but longer onset of analgesia, duration of analgesia and duration of recumbency than with LIG in diazepam-sedated goats. The epidural blockade also produced insignificant changes in the mean HR, RR, and RT responses of the experiment to both drug protocols.
Keywords: Bupivacaine, Epidural, Goats, Lignocaine; Loco-regional, Sedation