Nephrotic hyperlipidemia and atherothrombotic events in Nigerian Africans

  • NA Ifebunandu
  • MN Nwosu
  • MC Nwosu
  • JK Onwubualili
Keywords: Nephrotic Lipidaemia, Atherothromboembolic events Nigerians

Abstract

Background
Nephrotic hyperlipidaemia is a risk factor for atherothrombotic cardiovascular events. Directional changes in fractional lipidaemia appear to be more relevant. This study is aimed at determining the nature of association of nephrotic hyperlipidemia and atherothrobiotic event among
Nigerians.
Method
51 adult patients (35males and 16 females) seen consecutively at the university of Nigeria Teaching hospital and 48 (30 males, 18 females)
control subject were studies. Their 24hrs urine protein and serum albumin were determined. Their fasting serum cholesterol (TC), high density lipoprotein (HDL) low density lipoprotein (LDL), very low density Lipoprotein (VLDL) and triglyceride (TG) levels were determined. Their corresponding TC/HDL ratio were estimated. Atherothromboembolic makers were sought for and documented for both the patients and controls. Data obtained were treated parametrically with student –t- Test and non parametrically with the X2 test. P<0.05 was significant.
Results
The results showed that the mean ages of the patients and control  subjects were similar. All lipid fractions except HDL were significantly
elevated in nephrotics compared with the control (P<0.05) 70.7% of the patients had elevated TC, LDL and VLDL were elevated in 60.8% and
58.8% of the patients respectively. Skin rash, breathlessness and irregular pulse were significantly associated with abnormal TC/HDL ratio (P<0.05).
Conclusion
Nephrotic lipidemia is significantly associated with atherothromboembolic markers in our patients.
Section
Articles

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eISSN: 1119-0388