Hepato-curative effects of crude phenol root extract of soddom of apple (<i>C. Procera</i>) on CCL₄ induced hepatotoxicity in albino rats

Abstract

The effects of phenol root extracts of C. procera and livolin on liver function indices of CCl₄ induced hepatotoxicity was evaluated on forty (40) albino rats. The animals were grouped into four (I, II, III and IV) of 10 rats each, 120mg/kg of CCl4 was administered to rats in group II, III, and IV intramuscularly followed by oral administration of 10mg/kg livolin and phenol root extract of C. procera to group III and IV respectively. Analysis of variance (ANOVA) for multiple comparisms test were used to compare the result of the liver and kidney biochemical parameters from the test and control groups at 10 days interval for 20 days. The hepatic biochemical markers Alanine Aminotransferase (ALT), Aspartate Amino Transferases (AST), Alkaline Phosphatases (ALP) of the toxicant group (Gp II) were significantly higher (P<0.001), while group III (treated with livolin) statistically decreased (P<0.05) when compared with control (Gp I), this confirms the toxicity and treatment with livolin respectively. Oral administrations of the extracts at 10 days exposure lower all the liver function markers and increase the concentration of urea and albumin. This is an indication of the hepatocurative effect of the extract against CCl₄ induced rats. However, at 20 days exposure the activities of the liver markers were raised. The Histopathological photomicrograph showed moderate cytolysis and karyolysis.

Keywords: Hepatocurative, Calotropis Procera, hepatotoxicity, cytolysis, Carbon
tetrachloride.