The vegetable oils used as skin permeation enhancers were selected on the basis of compatibility studies data. A total of eight monolithic systems were prepared by using different concentrations of drug-polymers-permeation enhancers. The permeation parameters, flux, permeability coefficient, enhancement ratio and diffusion rate constants were determined. The maximum flux of 9.08 x 10-2 mg/cm2.h was observed with hydroxy propyl methyl cellulose monolithic system containing 30% w/w olive oil. Further improvement of flux was observed, when 30% w/w olive oil was applied directly onto the skin prior to the studies. The release was sustained up to 24 hours with zero-order kinetics and diffusion controlled mechanism. The 30% w/w olive oil formulation showed promising results with in vivo results showing significant analgesic and anti-inflammatory activities (P < 0.01) with no hypersensitivity reactions. Stability studies and scanning electron microscopy studies were also conducted.
Keywords: Vegetable oils, flux, ketoprofen, polymers
East and Central African Journal of Pharmaceutical Sciences Vol. 13 (2010) 19-24