Peripheral blood film - A review

Abstract

The peripheral blood film (PBF) is a laboratory work-up that involves  cytology of peripheral blood cells smeared on a slide. As basic as it is, PBF  is invaluable in the characterization of various clinical diseases. This article highlights the basic science and art behind the PBF. It expounds its  laboratory applications, clinical indications and interpretations in the light of  various clinical diseases. Despite advances in haematology automation and  application of molecular techniques, the PBF has remained a very important diagnostic test to the haematologist. A good quality smear, thorough  examination and proper interpretation in line with patient’s clinical state should be ensured by the haemato-pathologist. Clinicians should be abreast with its clinical utility and proper application of the reports in the management of patients.

Keywords: Peripheral blood smear, Preparation, Examination, Interpretation, Reporting, Blood cells morphology