Antimicrobial susceptibility assessment of compound from Aspergillus fumigatus

  • ZS Sathi
  • M Rahman
  • AL Faruk
  • MA Rashid
Keywords: Aspergillus, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, antimicrobial screening, bioactive compound.

Abstract

Ethyl acetate extract of the culture filtrate of Aspergillus fumigatus on chromatographic analysis has led to the isolation of the compound, AF-1 which exhibited a significant in vitro antimicrobial activity against the tested pathogenic microorganism. The structure of the isolated compound, AF-1 was identified as 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one from its IR, UV, EI-MS, 13C-NMR, 1H-NMR, HMBC and HMQC data. This is the first report of the compound, AF-1 from the A. fumigatus.

 

Key words: Aspergillus, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, antimicrobial screening, bioactive compound.

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eISSN: 1684-5315