The effect of Cordia platythyrsa on various experimental models of pain and carrageenan induced inflammation

  • Benedicta N Nkeh-Chungag
  • Eugene J Ndebia
  • Joseph T Mbafor
  • Lonwabo A Dotwana
  • OO Oyedeji
  • Jehu E Iputo

Abstract

Only one study has reported on the medicinal properties of Cordia platythyrsa (C. platythyrsa) though it is used in African traditional medicine for treatment of fever and pain. The current study aimed at investigating the analgesic and anti-inflammatory properties of C. platythyrsa using various animal models: writhing test, tail flick, thermal hyperalgesia, mechanically induced-pain, formalin-induced pain and carrageenan-induced inflammation tests. Like aspirin, the two doses of plant extracts used inhibited acetic acid-induced pain though these effects were weaker than the effects of morphine. Although, the plant extract significantly (p<0.01) inhibited thermal pain, its effects were less significant compared to morphine. Celecoxib (10 mg/kg) and plant extract (100 mg/kg) significantly inhibited thermal hyperalgesia compared to indomethacin. On the other hand, both doses of plant extract significantly increased mechanical pain thresholds 30 and 90 min post treatment. The plant extract (150 mg/kg) inhibited both the neurogenic and inflammatory pain phases of formalin-induced pain as well as carrageenan-induced inflammation. This study is the first to show that C. platythyrsa has analgesic and anti-inflammatory properties.

Keywords: Analgesia, pain, writhing, formalin, thermal hyperalgia

African Journal of Biotechnology, Vol. 13(2), pp. 343-348, 8 January, 2014

Author Biographies

Benedicta N Nkeh-Chungag
Zoology Department, Walter Sisulu University, PB X1, Mthatha 5117, South Africa
Eugene J Ndebia
Physiology Department, Faculty of Health Sciences, Walter Sisulu University, PB X1, Mthatha 5117, South Africa
Joseph T Mbafor
Department of Organic Chemistry, Faculty of Science, P. O. Box 812, University of Yaoundé I, Yaoundé Cameroon
Lonwabo A Dotwana
Physiology Department, Faculty of Health Sciences, Walter Sisulu University, PB X1, Mthatha 5117, South Africa
OO Oyedeji
Chemistry Department, University of Fort Hare, P/B X1314, Alice, 5700, South Africa
Jehu E Iputo
Physiology Department, Faculty of Health Sciences, Walter Sisulu University, PB X1, Mthatha 5117, South Africa
Published
2015-05-18
Section
Articles

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eISSN: 1684-5315