Effects of the methanol extract of Erythrina abyssinica on hot flashes in ovariectomized rats

  • Benedicta N Nkeh-Chungag
  • Sisanda Tiya
  • Joseph T Mbafor
  • Eugene J Ndebia
  • Sewani Rusike
  • Jehu E Iputo

Abstract

We investigated the estrogen-like properties of the methanol extract of Erythrina abyssinica in ovariectomized rats. Climaterix was induced in female rats by surgically removing the ovaries. Data loggers implanted in the abdominal cavity during the procedure recorded core temperatures at predetermined time intervals for 72 h. 6 h after the onset of temperature recording, animals were treated with estrogen (1 mg/kg), methanol extract of Erythrina abyssinica (200 mg/kg) or an equivalent volume of 5% ethanol. Rats treated with extract had significantly fewer hot flashes (171 ± 11 vs. 264 ± 21) which were of shorter duration (683 ± 137 min vs. 1935 ± 345 min) compared to untreated animals. Treated animals had lower core temperature during periods of high activity indicating that the methanol extract of E. abyssinica reduced frequency and duration of hot flashes.

Keywords: Ovariectomized, extract, Erythrina abyssinica, climaterix

African Journal of Biotechnology Vol. 12(6), pp. 598-601

Author Biographies

Benedicta N Nkeh-Chungag
Department of Zoology, Faculty of Science Engineering and Technology, PBx 1, Walter Sisulu University, Mthatha 5117, South Africa
Sisanda Tiya
Department of Physiology, Faculty of Health Sciences, PBx 1, Walter Sisulu University, Mthatha 5117, South Africa
Joseph T Mbafor
Department of Organic Chemistry, P. O. Box 812, University of Yaoundé 1, Yaoundé, Cameroon
Eugene J Ndebia
Department of Physiology, Faculty of Health Sciences, PBx 1, Walter Sisulu University, Mthatha 5117, South Africa
Sewani Rusike
Department of Physiology, Faculty of Health Sciences, PBx 1, Walter Sisulu University, Mthatha 5117, South Africa
Jehu E Iputo
Department of Physiology, Faculty of Health Sciences, PBx 1, Walter Sisulu University, Mthatha 5117, South Africa
Published
2015-12-03
Section
Articles

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eISSN: 1684-5315