Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals

  • Yun Hee Choi
  • Seung Sik Cho
  • Jaya Ram Simkhada
  • Chi Nam Seong
  • Hyo Jeong Lee
  • Hong Seop Moon
  • Jin Cheol Yoo

Abstract

An antimicrobial compound, highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin. The minimal inhibitory concentrations (MICs) of manumycin against 8 different strains of methicillin-resistant Staphylococcus aureus (MRSA) were ranged 2 to 32 μg/ml. Similarly, MICs of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains. Compared to vancomycin, manumycin provided slightly weaker activity against MRSA strains but stronger activity against 4 VRE strains. This is the first report of antagonistic effect of manumycin against MDR pathogens.

Keywords: Manumycin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE)

African Journal of Biotechnology Vol. 12(17), pp. 2249-2253

Author Biographies

Yun Hee Choi
Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea
Seung Sik Cho
Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam, 534-729, Korea.
Jaya Ram Simkhada
Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea
Chi Nam Seong
Department of Biology, College of Natural Sciences, Sunchon National University, Sunchon, Jeonnam, 540-742, Korea.
Hyo Jeong Lee
Department of Alternative Medicine, Gwangju University, Gwangju 503-703, Republic of Korea.
Hong Seop Moon
Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam, 534-729, Korea.
Jin Cheol Yoo
Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea.
Published
2016-01-29
Section
Articles

Journal Identifiers


eISSN: 1684-5315