Scoparia dulcis reduces the severity of Trypanosoma bruceiinduced hyperlipidaemia in the rabbit

  • NEJ Orhue
  • EAC Nwanze
Keywords: Scoparia dulcis, Trypanosoma brucei, cholesterol, triacylglycerol lipoproteins


We investigated the effect of oral administration of the herb, Scoparia dulcis, on Trypanosoma bruceiinduced changes in plasma lipid profile in rabbits over a period of twenty eight days. Results obtained show that infection with T. brucei resulted in significant increases in plasma total cholesterol,
trriacylglycerol, and low density lipoprotein (LDL)-cholesterol, while the level of high density lipoprotein (HDL)-cholesterol was also significantly reduced. Further comparative analysis of data revealed that these lesions were significantly less severe (p<0.05), in the infected and treated group relative to their untreated counterparts. However, the precise mechanism underlying the plasma lipid modulating effects of the herb is still a matter of speculations

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eISSN: 1684-5315