Effect of soy protein on serum lipid profile and some lipid-metabolizing enzymes in cholesterol fed rats

  • EC Onyeneke
  • OM Oluba
  • SI Ojeaburu
  • O Adeyemi
  • GE Eriyamremu
  • KE Adebisi
  • O Adeyemi
Keywords: Soy protein, cholesterol, lipid metabolizing enzymes.


The effect of soy protein on serum lipid profile and some lipid metabolizing enzymes in rats fed with cholesterol diets was examined in this study. Rats were subjected to feeding trial over a period of six
weeks on formulated diets containing: 20% soy protein with 0% cholesterol (group A), 20% soy protein with 5% cholesterol (group B), 20% soy protein with 10% cholesterol (group C), 0% soy protein with 20% cholesterol (group D), and 5% soy protein with 20% cholesterol (group E). Serum total, VLDL, LDL, and HDL-cholesterol and triglyceride concentrations were found to be reduced significantly in Groups B and C when compared with Groups D and E (p < 0.05). The lipid profile in group C did not, however, differ significantly when compared to the control group (p > 0.05). Groups D and E showed significant increased levels (p < 0.01) when compared to other groups. Lipoprotein lipase (LPL), lecithin:cholesterol acyl transferase (LCAT), and triglyceride lipase (TGL) activities were found to be significantly reduced (p< 0.05) in groups B and C when compared with groups D and E. Though groups B, C, D, and E rats all showed significant elevation (p < 0.05) in the enzyme activities when compared to the control.

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eISSN: 1684-5315