Comparative study of artesunate, ACTs and their combinants on the biochemical parameters of male guinea-pigs
AbstractIn this study, the effects of different doses of artesunate, artesunate/sulfadoxine/ pyrimethamine, artesunate/amodiaquine and their combinants (sulfadoxine/pyrimethamine and artesunate/
amodiaquine) on the biochemical parameters- alkaline phosphatase (ALP), total acid phosphatase (ACPT), prostatic acid phosphatase (ACPP), urea, creatinine, uric acid and total cholesterol of the male guinea-pig were investigated. Basal serum ACPP value was increased from 3.50 ± 0.42 to 4.75 ± 0.85 and 4.75 ± 0.48 IU/L by amodiaquine and sulfadoxine/pyrimethamine respectively at their subclinical
doses. These values were significant at p < 0.05. Furthermore, the agents caused no significant effects (p < 0.05) on serum ALP and ACPT. Artesunate/sulfadoxine/pyrimethamine significantly increased (p <
0.05) serum urea at the 3 doses, while the effects of artesunate and artesunate/amodiaquine were biphasic, decreasing basal serum urea level at lower doses and increasing at higher doses. However,
basal serum creatinine level was increased from 62.5 ± 6.7 to 89.8 ± 4.8 ìmol/L by sulfadoxine/pyrimethamine and decreased to 53.0 ± 0 ìmol/L by artesunate/amodiaquine at their subclinical doses, while the other agents caused no significant (p < 0.05) effects. Furthermore, control serum uric acid level was significantly decreased from 368.8 ± 10.0 to 318.3 ± 5.8, 306.0 ± 1.2 and 312.3 ± 2.6 mmol/L by artesunate, amodiaquine and artesunate/amodiaquine, after administration of half their clinical doses,
respectively. Total blood cholesterol was also significantly reduced from 2.43 ± 0.13 to 2.1 ± 0 and 1.9 ±0 mmol/L after administration of clinical doses of amodiaquine and artesinate/amodiaquine, respectively. These biochemical changes may be due to oxidative effects induced by these agents.