Anti-HIV-1 protease activities of crude extracts of some Garcinia species growing in Tanzania

  • JJ Magadula
  • S Tewtrakul
Keywords: Garcinia species, clusiaceae, crude extracts, HIV-1 protease, inhibitory effect


Eighteenth ethanol extracts from some Garcinia species in the Guttiferae (Clusiaceae) family collected in Tanzania were investigated for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC). Among the tested extracts, the fruit hulls of Garcinia
semseii showed the most potent inhibitory activity against HIV-1 PR with an IC50 value of 5.7 ìg/ml followed by the stem bark extracts of Garcinia edulis and Garcinia kingaensis with IC50 values of 9.2 and 15.2 ìg/ml, respectively. Phytochemical screening of extracts indicated mostly the presence of phenolic
and steroidal compounds.

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eISSN: 1684-5315