In vivo activities of Baicalin against Chlamydia trachomatis

  • Qi Xiaojuan
  • F Lei
  • S Wen
  • Y Yandong
  • H Hao
Keywords: Chlamydia trachomatis, Baicalin, vaginally infected

Abstract

Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model. It was demonstrated that Baicalin significantly reduced C. trachomatis
loading in BALB/c mice that were vaginally infected with the pathogen. On the basis of these data and our previous observations, we concluded that further evaluation of Baicalin for prevention and treatment of sexually transmitted chlamydial infection is warranted.
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eISSN: 1684-5315