African Journal of Biotechnology

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Studies on anti-ulcer, analgesic and antipyretic properties of the ethanolic leaf extract of Gongronema latifolium in rodents

GC Akuodor, MS Idris-Usman, CC Mbah, UA Megwas, JL Akpan, TC Ugwu, DO Okoroafor, UA Osunkwo


The ethanol extract of Gongronema latifolium leaves were evaluated for anti-ulcer, analgesic and anti pyretic activities in rats and mice. Ethanol-induced gastric ulceration, acetic acid-induced writhing and formalin-induced nociception were used. Yeast-induced hyperpyrexia was used to investigate the antipyretic activity. The extract produced a significant ulcer protective activity in rats. The extract also decreased pain induced both by acetic acid in mice and early phase of formalin test in rats. A significant reduction in hyperpyrexia was also produced by the extract in rats. This present study
provides a strong evidence of anti-ulcer, analgesic and antipyretic activities of G. latifolium.

AJOL African Journals Online