Studies on anti-ulcer, analgesic and antipyretic properties of the ethanolic leaf extract of Gongronema latifolium in rodents

  • GC Akuodor
  • MS Idris-Usman
  • CC Mbah
  • UA Megwas
  • JL Akpan
  • TC Ugwu
  • DO Okoroafor
  • UA Osunkwo
Keywords: Gongronema latifolium, analgesic, antipyretic, ulcer-protective

Abstract

The ethanol extract of Gongronema latifolium leaves were evaluated for anti-ulcer, analgesic and anti pyretic activities in rats and mice. Ethanol-induced gastric ulceration, acetic acid-induced writhing and formalin-induced nociception were used. Yeast-induced hyperpyrexia was used to investigate the antipyretic activity. The extract produced a significant ulcer protective activity in rats. The extract also decreased pain induced both by acetic acid in mice and early phase of formalin test in rats. A significant reduction in hyperpyrexia was also produced by the extract in rats. This present study
provides a strong evidence of anti-ulcer, analgesic and antipyretic activities of G. latifolium.
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eISSN: 1684-5315