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African Journal of Biotechnology

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Recent progress in the differentiation of bone marrow derived mesenchymal stem cells (BMMSCs) to cardiomyocyte- like cells and their clinical application

XB Yan, AL Lv, YJ Xing, L Wang, W Zhao

Abstract


Bone marrow mesenchymal stem cells (BMMSCs) are one of the cells found in bone marrow stromal. A large number of studies have shown that BMMSCs cannot only differentiate into hematopoietic stromal cells, but can migrate and position themselves in multiple non-hematopoietic organizations and differentiate into the corresponding tissue cells; this characteristic demonstrates their multilineage differentiation potential. In different conditions, BMMSCs can differentiate into bone, cartilage, fat, cardiomyocyte, endothelial cells and nerve cell, etc. Because BMMSCs are easy to acquire, they can proliferate in vitro, have multi-differentiation potential after implantation in vivo, and therefore have wide application prospects for the treatment of cardiovascular disease as the ideal seed cells. This review focuses on the biological characteristics of BMMSCs, the induction and differentiation of cardiomyocyte-like cells and the application in the cardiovascular field.


Key words: Bone marrow mesenchymal stem cells (BMMSCs), cardiomyocyte-like cells, cardiovascular disease.




AJOL African Journals Online