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African Journal of Biotechnology

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Ehrlich ascites carcinoma

M Ozaslan, ID Karagoz, IH Kilic, ME Guldur

Abstract


Experimental tumors have great importance in modeling, and Ehrlich ascites carcinoma (EAC) is one of the commonest tumors. EAC is referred to as an undifferentiated carcinoma and is originally hyperdiploid, has high transplantable capability, no-regression, rapid proliferation, shorter life span, 100% malignancy and also does not have tumor-specific transplantation antigen (TSTA). Frequently, tumor virulence increases via repetitious passages, while the proliferating rate of such tumors increases gradually. However, the differentiation gradually disappears, while the cells get free growth control mechanisms, gain hetero-transplantability and in the end, they are converted to the ascites’ form. EAC resembles human tumors which are the most sensitive to chemotherapy due to the fact that they are undifferentiated and that they have a rapid growth rate. The ideal drug being ineffective or minimally effective for normal cells have been focused on, and at this point, the usage of natural sources as an alternative cancer therapy is thought to have a great value for cancer control and programs’ destruction.

Key words: carcinoma, transplantability




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