Association of Gln27Glu polymorphism of the β-2- adrenergic receptor with preeclampsia

  • F Dogulu
  • M Özkur
  • E Dikensoy
  • M Nacak
  • N Benlier
  • AS Aynacioglu
Keywords: β-2-Adrenoceptor, preeclampsia, polymorphism.


The aim of the study was to assess the role of the β-2-adrenoceptor (ADRB2) polymorphisms occurring at amino acid positions 16 (arginin to glycine) and 27 (glutamine to glutamic acid) in preeclampsia. A group of 66 patients with preeclampsia and 72 control subjects were analyzed for the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Comparisons of the ADRB2 genotypes or alleles between different groups were performed using chi-square test. We found a significant association (P = 0.01) between the Gln27Glu substitution and preeclampsia. The Glu27 allele and Glu/Glu and Gln/Glu genotypes were significantly more common in preeclampsia group when compared with control subjects (25 versus 39%, P = 0.02 and 14 versus 5%, 50 versus 39%, P = 0.01, respectively). Our results imply that the existence of Glu27 allele may confer susceptibility to preeclampsia in Turkish population.

Key words: β-2-Adrenoceptor, preeclampsia, polymorphism.


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eISSN: 1684-5315