African Journal of Biotechnology

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Suppression of vascular smooth muscle cells’ proliferation and migration by valsartan via MAPK pathway

S Yan, J Xu, H Chen


This study aimed to determine the effects of valsartan on the proliferation and migration of isolated rat vascular smooth muscle cells (VSMCs) and the expression of phospho-p42/44 mitogen-activated protein kinase (MAPK) promoted by angiotensin II (Ang II). VSMCs from the rat thoracic aorta were cultured by attachment-block culture. VSMCs’ proliferation and migration were measured by MTT assay and migration chamber system, respectively. Phospho-p42/44 MAPK expression was determined by western blot. Our results reveal that valsartan inhibits Ang II-induced VSMCs’ proliferation and migration via suppression of Ang II-induced phospho-P42/44 MAPK expression.

Key words: Vascular smooth muscle, valsartan, angiotensin II, mitogen-activated protein kinase.
AJOL African Journals Online