Evaluation of antibacterial effects of Ficus cycomorus extracts on drug resistant Yersinia enterocolitica isolates associated with appendicitis in Kano State- Nigeria

Abstract

The study aimed at evaluating the effects of Ficus cycomorus extracts on resistant Yersinia enterocolitica isolates associated with appendicitis, processed and unprocessed meat samples in Kano state- Nigeria. Hospitals where appendectomies and laparotomies were carried out was randomly selected for the collection of appendiceal and stool samples from one hundred and ten patients (110) using judgmental sampling technique making total samples two hundred and twenty (220). One hundred and twenty (120) both processed (60) and unprocessed (60) meat samples were randomly collected for processing using culture and biochemical test (API 20E SYSTEM). Antibiogram, phytochemical screening, toxicity, and antibacterial activity of the plant extract on the isolates were also determined. The study revealed that Yersinia enterocolitica isolates from appendiceal and stool samples were found sensitive to gentamicin, ciprofloxacin, cifixime, chloramphenicol, and ceftriaxone and resistant to ampicillin while the isolates from unprocessed and processed meat samples were found sensitive to ampicillin, tetracycline, and cifixime and resistant to ceftrixone. The study revealed no significant difference in terms of susceptibility pattern of the isolates to conventional antibiotics (p=0.2). The study revealed insignificant difference (p=0.2) for extract of Ficus cycomorus on the isolates and the tolerability of the plant extracts for human use.