Analgesic and anti-inflammatory activities of the water extract from Terminalia chebula Rezt.
Background: In ayurvedic and Thai traditional medicine, the fruit of T. chebula is useful in arthritic disorders, inflammation, tumor, pains, chronic and recurrent fever. The study investigated the analgesic and anti-inflammatory activities in animal models.
Materials and methods: The water extract of T. chebula fruit was prepared and pain induced in mice by 0.1% formalin, before testing for the analgesic activity of the extract. The anti-inflammatory study was conducted in rats using four experimental models; ethyl phenylpropiolate or arachidonic acid-induced ear edema, carrageenan-induced paw edema and cotton pellet-induced granuloma formation.
Results: The T. chebula extract decreased licking times in mice injected with 0.1% formalin in both the early and late phases. Moreover, the extract inhibited rat ear edema induced by ethyl phenylpropiolate as well as in carrageenan-induced paw edema. In contrast, the extract did not have any inhibitory effect on arachidonic acid-induced ear edema in rats. The T. chebula extract did not reduce granuloma weight, body weight gain and thymus dry weight in cotton pellet-induced granuloma formation.
Conclusion: These results likely suggest that T. chebula water extract possess both analgesic and anti-inflammatory activities. The main mechanisms of action of T. chebula water extract may be due to the inhibitory effect on the synthesis and/or release of pain or inflammatory mediators
Keywords: Terminalia chebula Retz., analgesic activity, anti-inflammatory activity
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.