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Ethanol extract of <i>Carthamus tinctorius</i>L. shows anti-thrombosis activity in rats.


T Ding
L Jian
J Zhao
S Liu
J Zhang
SH Wu

Abstract

Background: The study was designed to study the anti-thrombosis activity of Carthamustinctorius L. (CTL) ethanol extraction rats.
Material and Methods: Common carotid artery FeCl3-induced thrombus and inferior vena cava thrombosis occlusion time, plasma concentrations of thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) were measured in rats.
Results: Venous occlusion time was prolonged in rats. Arterial and venous thrombus weights were dose-dependently reduced in CTL groups.TXB2 decreased and 6-keto-PGF1α increased with CTL and aspirin, with an association between 6-keto-PGF1α/TXB2 and arterial or venous thrombus weight for all products, and for occlusion time with CTL but not for aspirin.
Conclusion: The experimental effects of CTL on thrombosis in rats were confirmed. Again, further explorations of putative clinical effects appear justified.

Keywords: Carthamus tinctorius L.; thrombosis; TXB2; 6-keto-PGF1α.