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The efficacy and safety of <i>Urtica dioica</i> in treating benign prostatic hyperplasia: a systematic review and meta-analysis

Changping Men
Meng Wang
Maimaiti Aiyireti
Yuanshan Cui


Background: Urtica dioica is extract from the root of a stinging nettle.
Materials and Methods: We carried out a systematic review and meta-analysis to assess the efficacy and safety of Urtica dioica for treating Benign prostatic hyperplasia (BPH). A literature review was performed to identify all published randomized double-blind, controlled trials of Urtica dioica for the treatment of BPH. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated.
Results: Five publications involving a total of 1128 patients were used in the analysis. Primary efficacy end points: the international prostate symptom score (IPSS) (the standardized mean difference (SMD) =-10.47, 95% confidence interval (CI) =-18.12 to -2.82, p=0.007); the peak urinary flow rate (Qmax) (SMD=4.37, 95%CI=1.55 to 7.19, p=0.002) and prostate volume (SMD=-3.63, 95%CI=-4.67 to -2.57, p<0.00001) indicated that Urtica dioica was more effective than the placebo or controls. Safety assessments included prostatic specific antigen (PSA) (SMD=-0.08, 95%CI=-0.23 to 0.07, p=0.31) showed that PSA levels were unaffected in both groups.
Conclusion: This meta-analysis indicates that Urtica dioica to be an effective and safe treatment for LUTS associated with BPH.

Key words: Urtica dioica, lower urinary tract symptoms, benign prostatic hyperplasia, meta-analysis, Randomized controlled trial

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eISSN: 0189-6016